Niko Syrup 60ml

Mechanism of Action (MOA):

• Paracetamol works by inhibiting the synthesis of prostaglandins in the central nervous system and blocking peripheral pain impulse generation. It also acts on the hypothalamic heat-regulating center to reduce fever.

Dosage and Administration:

• Children 2 to 3 years (11-16 kg): 5 mL (125 mg) every 4 to 6 hours as needed, not exceeding 4 doses (500 mg) in 24 hours.
• Children 4 to 5 years (17-20 kg): 7.5 mL (187.5 mg) every 4 to 6 hours as needed, not exceeding 4 doses (750 mg) in 24 hours.
• Children 6 to 8 years (21-25 kg): 10 mL (250 mg) every 4 to 6 hours as needed, not exceeding 4 doses (1,000 mg) in 24 hours.
• Children 9 to 10 years (26-32 kg): 12.5 mL (312.5 mg) every 4 to 6 hours as needed, not exceeding 4 doses (1,250 mg) in 24 hours.
• Children 11 to 12 years (33-43 kg): 15 mL (375 mg) every 4 to 6 hours as needed, not exceeding 4 doses (1,500 mg) in 24 hours.
• Administration: Shake well before use. Use the provided measuring device to ensure accurate dosing.

Side Effects:

• Paracetamol is generally well-tolerated. Possible side effects include:
  • Allergic reactions (e.g., rash, itching, swelling)
  • Gastrointestinal disturbances (e.g., nausea, vomiting)
  • Rare cases of hematological reactions (e.g., thrombocytopenia, leukopenia)
  • Hepatotoxicity with excessive dosing

Drug Interactions:

• Concurrent use with other medications containing paracetamol can lead to overdose.
• May enhance the effects of anticoagulants like warfarin with prolonged use.
• Alcohol consumption may increase the risk of liver damage.
• Consult a healthcare professional before combining with other medications.

Precautions:

• Do not exceed the recommended dosage.
• Use with caution in patients with liver or kidney impairment.
• Not recommended for use in infants under 2 months without medical advice.
• Seek medical attention if symptoms persist for more than 3 days or worsen.
• Store at room temperature, away from light and moisture. Keep out of reach of children.