Deriva CMS Gel
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₨ 606.00
- Brand Name: Deriva-CMS Gel
- Manufacturer: Glenmark Pharmaceuticals Ltd.
- Generic Name: Adapalene (0.1% w/w) + Clindamycin Phosphate (1% w/w)
- Class of Drug: Topical Retinoid and Antibiotic Combination
- Dosage Form: Gel, 15g tube
- Use of Drug: Treatment of acne vulgaris
Mechanism of Action (MOA):
- Adapalene: A retinoid-like compound that modulates cellular differentiation, keratinization, and inflammatory processes, thereby preventing the formation of new acne lesions and promoting the turnover of skin cells.
- Clindamycin Phosphate: An antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, effectively targeting acne-causing bacteria and reducing inflammation.
Dosage and Administration:
- Adults and Adolescents (12 years and older): Apply a thin layer of Deriva-CMS Gel to the affected area once daily, preferably in the evening, after cleansing and drying the skin.
- Children under 12 years: Not recommended.
Side Effects:
Common side effects may include:
- Skin irritation
- Dryness
- Redness
- Peeling
These side effects are generally mild and tend to resolve with continued use.
Drug Interactions:
Avoid concurrent use of other topical acne treatments containing retinoids or antibiotics unless directed by a healthcare professional, as this may increase the risk of skin irritation.
Precautions:
- Sun Exposure: Use sunscreen and protective clothing to minimize exposure to sunlight, as adapalene can increase skin sensitivity to UV rays.
- Pregnancy and Lactation: Consult a healthcare provider before use.
- Allergic Reactions: Discontinue use if severe skin reactions or allergies occur.
