Sartel 40mg

Mechanism of Action (MOA):

Telmisartan, the active ingredient in Sartel 40mg, is an Angiotensin II Receptor Blocker (ARB). It works by blocking the action of angiotensin II, a hormone that constricts blood vessels. By inhibiting this action, telmisartan relaxes and dilates blood vessels, leading to a reduction in blood pressure and a decreased risk of cardiovascular events.

Dosage and Administration:

• Adults:
  • The typical starting dose is 40 mg once daily.
  • Depending on individual response and therapeutic goals, the dose may be adjusted up to a maximum of 80 mg once daily.
• Administration:
  • Take the tablet at the same time each day, with or without food.
  • Swallow the tablet whole with water; do not crush or chew.

Side Effects:

• Common:
  • Headache
  • Dizziness
  • Back pain
  • Abdominal pain
  • Diarrhea
• Serious:
  • Angioedema (swelling of deeper layers of the skin)
  • Hyperkalemia (elevated potassium levels)
  • Hypotension (low blood pressure)

Drug Interactions:

• Concurrent use with potassium supplements, potassium-sparing diuretics, or potassium-containing salt substitutes may increase the risk of hyperkalemia.
• Use with caution when co-administered with other antihypertensive agents, as it may lead to an additive blood pressure-lowering effect.

Precautions:

• Renal Impairment: Monitor kidney function regularly; dose adjustments may be necessary.
• Hepatic Impairment: Use with caution; not recommended in severe liver impairment.
• Pregnancy and Lactation: Contraindicated during pregnancy, especially in the second and third trimesters, as it may harm the fetus. Not recommended during breastfeeding.
• Electrolyte Imbalances: Regular monitoring of potassium levels is advised, as hyperkalemia can occur.