Rosutab-5mg

Mechanism of Action (MOA):

Rosuvastatin works by inhibiting HMG-CoA reductase, an enzyme responsible for the synthesis of cholesterol in the liver. This inhibition leads to a reduction in hepatic cholesterol production, resulting in increased uptake of LDL cholesterol from the bloodstream and a subsequent decrease in overall blood cholesterol levels.

Dosage and Administration:

• Adults:
  • The recommended starting dose is 5 mg once daily. Depending on individual response and therapeutic goals, the dose may be adjusted up to a maximum of 40 mg once daily.
• Elderly (Over 70 years):
  • A starting dose of 5 mg is recommended. No dose adjustment is necessary based solely on age.
• Renal Impairment:
  • For patients with an estimated glomerular filtration rate (eGFR) between 30-60 mL/min/1.73 m², initiate with 5 mg once daily (do not exceed 20 mg daily). Avoid use if eGFR is less than 30 mL/min/1.73 m².
• Administration:
  • Take the tablet at any time of day, with or without food.
  • Swallow the tablet whole with water.

Side Effects:

• Common:
  • Headache
  • Muscle pain or weakness
  • Abdominal pain
  • Nausea
  • Dizziness
• Serious:
  • Myopathy and rhabdomyolysis
  • Liver enzyme abnormalities
  • Severe allergic reactions

Drug Interactions:

• Concurrent use with gemfibrozil significantly increases rosuvastatin exposure, raising the risk of myopathy/rhabdomyolysis. Combination therapy should be avoided.
• Use with caution when co-administered with atazanavir, darunavir, ezetimibe, fibrates, itraconazole, lopinavir, or tipranavir; dose adjustments may be necessary.

Precautions:

• Renal Impairment: Use with caution; dose adjustments may be necessary.
• Hepatic Impairment: Contraindicated in patients with active liver disease or unexplained persistent elevations of liver transaminases.
• Pregnancy and Lactation: Contraindicated; may cause fetal harm.
• Alcohol Consumption: Limit intake due to potential liver effects.
• Asian Ancestry: Increased systemic exposure has been observed; a starting dose of 5 mg is recommended, and the 40 mg dose is contraindicated.